The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.



PROLOTHERAPY
Journal of Prolotherapy International Medical Editorial Board Concensus Statement on the Use of Prolotherapy for Musculoskeletal Pain.
This paper discusses the theory, scientific evidence, methods and applications for Prolotherapy and the different types of Prolotherapy in the treatment of musculoskeletal pain.   

The New York Times August 2007
"A leader in the field."  Dr. Donna Alderman, an osteopathic physician who is medical director of the Hemwall Center for Orthopedic Regenerative Medicine.  "The technique reactivates the healing process by injecting a mildly irritating substance - commonly a somewhat concentrated sugar solution along with the pain killer Lidocaine - into the injured area to stimulate a temporary low-grade inflammation. In some cases, growth factors themselves may be injected."

"Prolotherapy" Chapter 18
Donna Alderman, Complementary and Integrative Medicine in Pain Management. 
Editors: Weintraub, Mamtani and Micozzi., Springer Publishing Company, New York, 2008

A History of the American College of Osteopathic Sclerotherapeutic Pain Management, the Oldest Prolotherapy Organization
Donna Alderman, DO
Nov 2009, Journal of Prolotherapy

Prolotherapy for Musculoskeletal Pain
Donna Alderman, DO
"Prolotherapy, considered an alternative therapy, is quietly establishing itself in mainstream medicine because of its almost irresistible draw for both physicians and patients: nonsurgical treatment for musculoskeletal conditions."
Jan/Feb 2007, Practical Pain Management Journal

Prolotherapy For Knee Pain
Donna Alderman, DO
July/August 2007, Practical Pain Management Journal

Prolotherapy For Low Back Pain
Donna Alderman, DO
May 2007, Practical Pain Management Journal

Dextrose Prolotherapy Injections for Chronic Ankle Pain
Ross A. Hauser, MD; Marion A. Hauser, MS, RD; and Joe Cukla, BA, LPN
Jan/Feb 2010, Practical Pain Management Journal

Dextrose Prolotherapy for Unresolved Wrist Pain
Ross A. Hauser, MD; Marion A. Hauser, MS, RD; and Patricia Holian, RN
Nov/Dec 2009, Practical Pain Management Journal

Hackett-Hemwall Dextrose Prolotherapy for Unresolved Elbow Pain
Ross A. Hauser, MD; Marion A. Hauser, MS, RD; and Patricia Holian, RN
Oct 2009, Practical Pain Management Journal

Dextrose Prolotherapy for Recurring Headache and Migraine Pain
Ross A. Hauser, MD and Heather McCullough, MA
June 2009, Practical Pain Management Journal

Mayo Clinic Newsletter 2005
"In the case of chronic ligament or tendon pain that hasn't responded to more conservative treatments such as prescribed exercise or physical therapy, Prolotherapy may be helpful."  

Prolotherapy for Golfing Injuries and Pain
Donna Alderman, DO
June 2008, Practical Pain Management Journal

Dextrose Prolotherapy and Pain of Chronic TMJ Dysfunction
Ross A. Hauser, MD; Marion A. Hauser, MS, RD; and Krista A. Blakemore, BA
Nov/Dec 2007, Practical Pain Management Journal

Dextrose Prolotherapy For Unresolved Neck Pain
Ross A. Hauser, MD and Marion A. Hauser, MS, RD
Oct 2007, Practical Pain Management Journal

Prolotherapy In Primary Care
David Rabago, MD, Andrew Slattengren, DO and Aleksandra Zgierska, MD
March 2010, Primary Care Journal

Dextrose Prolotherapy and Pain of Chronic TMJ Dysfunction
Ross A. Hauser, MD; Marion A. Huaser, MS and Krista A Blakemore, BA
Nov/Dec 2007, Practical Pain Management Journal



PRP PROLOTHERAPY
The New Age of Prolotherapy
Donna D. Alderman, DO
In addition to traditional Prolotherapy, platelet-rich plasma and stem cells are also available to enhance healing of musculoskeletal injuries and mitigation of pain. 
May 2010, Practical Pain Management Journal

Mayo Clinic Newsletter March 2010
When tendon trouble - such as tennis elbow or Achilles tendon pain - doesn't respond to traditional treatment, an injection of the patient's own blood plasma into the tendon may provide relief.

Platelet Rich Plasma in Prolotherapy
Donna Alderman, DO
Jan/Feb 2009, Practical Pain Management Journal

Platelet Rich Plasma for Rotator Cuff Tendon Tear
Donna D. Alderman, DO
Platelet rich plasma (PRP) Prolotherapy continues to increase in use in orthopedics, with the American Academy of Orthopaedic Surgeons summarizing that available data suggest PRP may be valuable in enhancing soft-tissue repair and wound healing.  
September 2012, Practical Pain Management Journal

Platelet Rich Plasma Prolotherapy for Low Back Pain Caused by Sacroiliac Joint Laxity
Gordon KO, MD
Aug 2010, Practical Pain Management

Platelet Rich Plasma Prolotherapy as First-Line Treatment for Meniscal Pathology
Ross A. Hauser, MD; Hilary J. Philips; and Havil Maddela
Jul/Aug 2010, Practical Pain Management Journal

Platelet Rich Plasma for Hamstring Tears
By David C. Karll, MD and Brent R. Robinson, BS
June 2010, Practical Pain Management Journal

Platelet Rich Plasma (PRP) Matrix Grafts
David Crane, MD and Peter A.M. Everts, PhD
Jan/Feb 2008, Practical Pain Management Journal

PRP for Proximal Plantar Fasciits
Mark Scioli, DPM
March 2011, Techniques in Foot and Ankle Surgery

Platelet-Rich Plasma Intraarticular Knee Injections Produced Favorable Results on Degenerative Cartilage Lesions
Elizaveta Kon et al.
October 2009, Knee Surg Sports Traumatol Arthroscopy



BIOCELLULAR PROLOTHERAPY
Stem Cell Prolotherapy in Regenerative Medicine:  Background, Theory and Protocols
Donna D. Alderman, DO and Robert W. Alexander, MD, et al.
August 2011, Journal of Prolotherapy

Advances in Regenerative Medicine: High-density Platelet-rich Plasma and Stem Cell Prolotherapy For Musculoskeletal Pain
Donna D. Alderman, DO and Robert W. Alexander, MD
Oct 2011, Practical Pain Management Journal

Autologous Fat Grafts as  Mesenchymal Stromal Stem Cell Source for use in  Prolotherapy: A Simple Technique to Acquire  Lipoaspirants
Robert W. Alexander, MD, DMD, FICS
August 2011, Journal of Prolotherapy

Autologous Fat Grafting as a  Mesenchymal Stem Cell Source and Living  Bioscaffold in a Patellar Tendon Tear
Joseph J. Albano, MD and Robert W. Alexander, MD
July 2011, Clinical Journal of Sports Medicine

Regenerative Medicine in the Field of Pain Medicine:  Prolotherapy, Platelet-rich Plasma Therapy, and  Stem Cell Therapy - Theory and Evidence
David M. DeChellis, DO and Megan Helen Cortazzo, MD
“As increasing evidence on regenerative medicine is generated, more interventional pain physicians are looking to use this field.”