Dextrose Prolotherapy is the original form of Prolotherapy originating in the 1930’s. Concentrated dextrose (sugar water) or saline (salt water) or other natural substances, are used as an irritant to stimulate a mild inflammation which “tricks” the body into thinking the area is injured and to begin healing again. Dextrose Prolotherapy raises growth factor levels or effectiveness to promote tissue repair, reducing or eliminating musculoskeletal pain.
Dextrose Prolotherapy is practiced by physicians in the U.S. and worldwide, has been shown effective in treating many musculoskeletal conditions - such as tendinopathies, ligament sprains, back and neck pain, tennis/golfers elbow, ankle pain, joint laxity and instability, plantar fasciitis, shoulder, knee pain and other joint pain. It is commonly referred to as simply “Prolotherapy”.
How Prolotherapy Works
Prolotherapy works by causing a temporary, low grade inflammation at the injection site, activating fibroblasts to the area, which, in turn, synthesize precursors to mature collagen and thus reinforce connective tissue. It has been well documented that direct exposure of fibroblasts to growth factors (either naturally occurring or added) causes new cell growth and collagen deposition. Inflammation creates secondary growth factor elevation. The inflammatory stimulus of Prolotherapy raises the level of growth factors to resume or initiate a new connective tissue repair sequence which had prematurely aborted or never started. Animal biopsy studies show ligament thickening, enlargement of the tendinosseous junction, and strengthening of the tendon or ligament after Prolotherapy injections.
Prolotherapy for Musculoskeletal Pain.
Practical Pain Management, January/February 2007.