The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

Degenerative Disc Disease

Treatment of Lumbar Degenerative Disc Disease with Adipose Derived Stromal Vascular Fraction, Point of Care. (2012)
This is the first reported case report where nonexpanded cell therapy was used to successfully treat advanced degenerative disc disease. 

Effect of Autologous Platelet-Rich-Plasma-Releasate on Intervertebral Disc Degeneration in the Rabbit Anular Puncture Model: A Preclinical Study. (2012)
The administration of platelet-rich plasma increased the number of cartilage cells and disc height in back arthritis in this animal model. 

Prolotherapy for Low Back Pain. (2007)
This review article discusses the why and how Prolotherapy works to help resolve low back pain with case reports provided. 

Treatment of Painful Advanced Internal Lumbar Disc Derangement with Intradiscal Injection of Hypertonic Dextrose. (2006)
Injections of concentrated dextrose into the disc resulted in improvement in pain, often long lasting, sometimes after only one treatment, with no adverse side effects.

Prolotherapy Injections, Saline Injections and Exercises for Chronic Low Back Pain: A Randomized Trial.  (2004)
Significant and sustained reductions in pain and disability occurred with both dextrose and saline prolotherapy injections, with or without exercise. 

Biochemical Injection Treatment for Discogenic Low Back Pain: A Pilot Study. (2002)
This study evaluates various substances, including concentrated dextrose (Prolotherapy)  for their effectiveness with disc degeneration.  Results were positive.