[1] Alternative treatments: Dealing with chronic pain. Mayo Clinic Health Letter. 2005 April; 23(4) [cited 2022 March 22] Mayo-Clinic-Prolo-(2005).pdf
[2] Tendon Trouble: New treatment uses enhanced plasma. Mayo Clinic Health Letter. 2010 March, p.7 [cited 2022 March 22] Mayo Clinic newlsetteron PRP for treating tendon trouble-(2010).pdf.
[3] Mayo Clinic Health System. Physical Medicine & Rehabilitation Department information page [cited 2022 March 19] mayoclinichealthsystem.org/locations/faribault/services-and-treatments/physical-medicine-and-rehabilitation/, Mayo Clinic Center for Regenerative Medicine [Internet]. Musculoskeletal Regeneration. [cited 2022 March 19] mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/musculoskeletal-regeneration
[4] Dreher G. Platelet-rich plasma (PRP) injections. John Hopkins website [cited 2022 March 26]. https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment; Platelet Rich Plasma – PRP - Therapy. Cedar Sinai website. [cited 2022 March 26]. https://www.cedars-sinai.org/programs/imaging-center/exams/musculoskeletal-radiology/platelet-rich-plasma.html; Physical Medicine and Rehabilitation, Stanford Health Care [cited 2022 March 26]. https://valleycare.com/medical-clinics/physical-medicine-rehabilitation.html; Advances in non-surgical regenerative techniques, Massachusetts General Hospital website [cited 2022 March 26]. https://advances.massgeneral.org/ortho/video.aspx?id=1049 ; Weill Cornell Medicine Center for Comprehensive Spine Care, Platelet rich plasma injections [cited 2022 March 26]. weillcornell.org/treatments/platelet-rich-plasma-injections/
[5] Liu YK, Tipton CM, Matches RD, Bedford TG, Maynard JA, Walmer HC. An in situ study of a sclerosing solution in rabbit medical collateral ligaments and its junction strength. Connective Tissue Research. 1983; 11(2–3): 95–102.
[6] Maynard JA, Pedrini VA, Pedrini‐Mille A, Romanus B, Ohlerking F. Morphological and biochemical effects of sodium morrhuate on tendons. Journal of Orthopaedic Research. 1985; 3(2): 236–248.
[7] Klein RG, Dorman TA, Johnson CE. Proliferant injections for low back pain: Histologic changes of injected ligaments and objective measures of lumbar spine mobility before and after treatment. Journal of Neurological and Orthopaedics Medicine and Surgery. 1989; 10: 141–144.
[8] Reeves KD, Hassanein K. Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: Evidence of clinical efficacy. Journal of Alternative & Complementary Medicine. 2000 Aug; 6(4): 311–320.
[9] Dechow E, Davies RK, Carr AJ, Thompson PW. A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain. Rheumatology. 1999; 38(12): 1255–1259; Klein RG, Eek BC, DeLong WB, Mooney V. A randomized double-blind trial of dextrose-glycerine-phenol injections for chronic, low back pain. Journal of Spinal Disorders & Techniques. 1993; 6(1): 23–33.
[10] Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, Zgierska A. Dextrose prolotherapy for knee osteoarthritis: A randomized controlled trial. Annals of Family Medicine. 2013; 11(3): 229–237.
[11] Reeves KD, Hassanein K. Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Alternative Therapies in Health and Medicine. 2000; 6(2): 68–80.
[13] Refai H, Altahhan O, Elsharkawy R. The efficacy of dextrose prolotherapy for temporomandibular joint hypermobility: A preliminary prospective, randomized, double-blind, placebo-controlled clinical trial. Journal of Oral and Maxillofacial Surgery. 2011; 69(12): 2962–2970.
[14] Bertrand H, Reeves KD, Bennett CJ, Bicknell S, Cheng AL. Dextrose prolotherapy versus control injections in painful rotator cuff tendinopathy. Archives of Physical Medicine and Rehabilitation. 2016; 97(1): 17–25.
[15] Reeves KD, Hassanein KM. Long term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Alternative Therapies in Health and Medicine.2003; 9(3): 58–62.
[16] Topol GA, Reeves KD, Hassanein KM. Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain. Archives of Physical Medicine and Rehabilitation. 2005; 86(4): 697–702.
[17] Hauser RA, Hauser MA, Page RD. Dextrose prolotherapy for unresolved neck pain. Practical Pain Management. 2007; 7(8): 56–60; Hooper RA, Ding M. Retrospective case series on patients with chronic spinal pain treated with dextrose prolotherapy. Journal of Alternative & Complementary Medicine. 2004; 10(4): 670–674.
[18] Steilen D, Hauser R, Woldin B, Sawyer S. Chronic neck pain: Making the connection between capsular ligament laxity and cervical instability. Open Orthopaedics Journal. 2014; 8: 326; Hooper RA, Frizzell JB, Faris P. Case series on chronic whiplash-related neck pain treated with intraarticular zygapophysial joint regeneration injection therapy. Pain Physician. 2007; 10(2): 313–318.
[19] Kim WM, Lee HG, Jeong CW, Kim CM, Yoon MH. A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. Journal of Alternative and Complementary Medicine. 2010; 16(12): 1285–129.
[20] Ryan MB, Wong AD, Gillies JH, Wong J, Taunton JE. Sonographically guided intratendinous injections of hyperosmolar dextrose/lidocaine: a pilot study for the treatment of chronic plantar fasciitis. British journal of sports medicine. 2009 Apr 1; 43(4): 303–306.
[21] Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, Kijowski R, Grettie J, Wilson J, Miller D. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level randomized controlled trial. American Journal of Physical Medicine & Rehabilitation/Association of Academic Physiatrists. 2013; 92(7): 587.
[22] Hackett GS, Henderson DG. Joint stabilization: An experimental, histologic study with comments on the clinical application in ligament proliferation. American Journal of Surgery. 1955; 89(5): 968–973.
[23] Caring Medical Regenerative Medicine Clinics. Hackett Hemwall Hauser = H3 Prolotherapy. [cited 2022 March 19] https://www.caringmedical.com/prolotherapy/hackett-hemwall-prolotherapy/.
[24] Kiliç CS, Güngörmüş M. Is dextrose prolotherapy superior to placebo for the treatment of temporomandibular joint hypermobility? A randomized clinical trial. International Journal of Oral and Maxillofacial Surgery. 2016; 45(7): 813–819.
[25] University of Alberta. Platelet-rich plasma injections may lead to improvements in tissue healing. Science Daily.2016 March 2 [cited 2022 March 19] sciencedaily.com/releases/2016/03/160302132531.htm.
[26] Paterson KL, Nicholls M, Bennell KL, Bates D. Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: A double-blind, randomized controlled pilot study. BMC Musculoskeletal Disorders. 2016; 17(1): Görmeli G, Görmeli CA, Ataoglu B, Çolak C, Aslantürk O, Ertem K. Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: A randomized, double-blind, placebo-controlled trial. Knee Surgery, Sports Traumatology, Arthroscopy. 2015: 1–8; Sandeep P, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis a prospective, double-blind, randomized trial. American Journal of Sports Medicine. 2013; 41(2): 356–364; Smith PA. Intra-articular autologous conditioned plasma injections proved safe and efficacious treatment for knee osteoarthritis: An FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial. American Journal of Sports Medicine. 2016; 44(4): 884–891.
[27 Tuakli-Wosornu YA, Terry A, Boachie-Adjei K, Harrison JR, Gribbin CK, LaSalle EE, Nguyen JT, Solomon JL, Lutz GE. Lumbar intradiskal platelet-rich plasma (PRP) injections: A prospective, double-blind, randomized controlled study. PM&R. 2016; 8(1): 1–10.
[28] Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-rich plasma as a treatment for patellar tendinopathy: a double-blind, randomized controlled trial. American Journal of Sports Medicine. 2014; 42(3): 610–618.
[29] Hauser RA, Phillips HJ, Maddela H. Platelet rich plasma Prolotherapy as first-line treatment for meniscal pathology. Practical Pain Management. 2010 Jul; 10(6): 53–64.
[30] de Jonge S, de Vos RJ, Weir A, van Schie HTM, Bierma-Zeinstra SMA, Verhaar JAN, Weinans H, Tol JL. One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy a double-blind randomized placebo-controlled trial. American Journal of Sports Medicine. 2011; 39(8): 1623–1629.
[31] Ko GD, Mindra S, Lawson GE, Whitmore S, Arseneau L. Case series of ultrasound-guided platelet-rich plasma injections for sacroiliac joint dysfunction. Journal of Back and Musculoskeletal Rehabilitation. 2016; 30(2): 363–370.
[32] Mishra AK, Skrepnik NV, Edwards SG, Jones GL, Sampson S, Vermillion DA, Ramsey ML, Karli DC, Rettig AC. Platelet-rich plasma significantly improves clinically outcomes in patients with chronic tennis elbow: A double-blind, prospective, multicenter, controlled trial of 230 patients. American Journal of Sports Medicine. 2013; (42)2: 463–471; Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. American Journal of Sports Medicine. 2010; 38(2): 255–262.
[33] Deal JB, Smith E, Heard W, O’Brien MJ, Savoie III FH. Platelet-Rich Plasma for Primary Treatment of partial ulnar collateral ligament tears: MRI correlation with results. Orthopaedic Journal of Sports Medicine. 2017 Nov 8; 5(11) [cited 2022 March 19]. journals.sagepub.com/doi/full/10.1177/2325967117738238.
[34] Gosens T, Peerbooms JC, van Laar W, den Oudsten BL. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: A double-blind, randomized controlled trial with 2-year follow up. American Journal of Sports Medicine. 2011; 39(6): 1200–1208.
[35] Singh A, Goel SC, Gupta KK, Kumar M, Arun GR, Patil H, Kumaraswamy V, Jha S. The role of stem cells in osteoarthritis. Bone & Joint Research. 2014; 3: 32–37.
[36] Perdisa F, Gostyńska N, Roffi A, Filardo G, Marcacci M, Kon E. Adipose-derived mesenchymal stem cells for the treatment of articular cartilage: A systematic review on preclinical and clinical evidence. Stem Cells International. 2015; Article ID 597652,13 pages.
[37] Bui, KHT, Duong TD, Nguyen NT, Nguyen TD, Le VT, Mai VT, Phan N, Le DM, Phan NK, Pham PV. “Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: A clinical study.” Biomedical Research and Therapy. 2014; 1(1): 2–8.
[38] Koh, YG, Choi YJ, Kwon SK, Kim YS, Yeo JE. Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy. May 2015; 23(5): 1308–1316.
[39] Oe K, Kushida T, Okamoto N, Umeda M, Nakamura T, Ikehara S, Iida H. New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats. Stem Cells and Development. 2011; 20(4): 671–679; Soon MY, Hassan A, Hui JHJ, Goh JC, Lee EH. An analysis of soft tissue allograft anterior cruciate ligament reconstruction in a rabbit model: a short-term study of the use of mesenchymal stem cells to enhance tendon osteointegration. The American Journal of Sports Medicine. 2007; 35(6): 962–971.
[40] Albano JJ, Alexander RW. Autologous fat grafting as a mesenchymal stem cell source and living bioscaffold in a patellar tendon tear. Clinical Journal of Sport Medicine. 2011; 21(4): 359–361.
[41] Alexander RW. Biocellular regenerative medicine: Use of adipose-derived stem/stromal cells and its native bioactive matrix. Physical Medicine & Rehabilitation Clinics of North America. 2012; 27: 871–891.
[42] Oliver KS, Alexander RW. Combination of autologous adipose-derived tissue stromal vascular fraction plus high density platelet-rich plasma or bone marrow concentrates in Achilles tendon tears. Journal of Prolotherapy. 2013; 5: e895–e912.
[43] Journal of Prolotherapy [cited 2022 March 19] journalofprolotherapy.com.
[44] Solomon DJ. The role of peer review for scholarly journals in the information age. The Journal of Electronic Publishing. 2007; 10(1) [cited 2022 March 19] http://quod.lib.umich.edu/j/jep/3336451.0010.107?view=text;rgn=main.
[45] Hauser RA, Maddela HS, Alderman DD, Baehnisch G, Banner R, Blakemore PJ, Calderón JE, Clark GB, DeLaurentis M, Fauley S, Funck J, Gladstein B, Johnson ML, Kramer GH, Neustadt J, Resk J, Salazar JH, Swetlikoff G, Van Pelt RS, Wheaton MT. Journal of Prolotherapy international medical editorial board consensus statement on the use of prolotherapy for musculoskeletal pain. Journal of Prolotherapy. 2011; 3(4): 744–764.
[46] PM&R: The Journal of Injury, Function and Rehabilitation. [cited 2022 March 19] www.pmrjournal.org/content/aims.
[47] The American Osteopathic Association of Prolotherapy Regenerative Medicine. Teaching physicians since 1938. Committed to the long term education of Prolotherapy [cited 2022 March 19] prolotherapycollege.org/.
[48] Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health. The UW Prolotherapy Education and Research Lab (UWPEARL): Advancing a promising treatment for chronic pain [cited 2022 March 19] www.fammed.wisc.edu/prolotherapy/.
[49] Rabago D, Slattengren A, Zgierska A. Prolotherapy in primary care practice. Primary Care: Clinics in Office Practice. 2010; 37(1): 65–80; Rabago D, Best TM, Zgierska AE, Zeisig E, Ryan M, Crane D. A systematic review of four injection therapies for lateral epicondylosis: Prolotherapy, polidocanol, whole blood and platelet-rich plasma. British Journal of Sports Medicine. 2009; 43(7): 471–481; Scarpone M, Rabago D, Zgierska A, Arbogest J, Snell E. The efficacy of prolotherapy for lateral epicondylosis: A pilot study. Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine. 2008; 18(3): 248; Rabago D, Best TM, Beamsley M, Patterson J. A systematic review of prolotherapy for chronic musculoskeletal pain. Clinical Journal of Sport Medicine. 2005; 15(5): E376; Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, Zgierska A. Dextrose prolotherapy for knee osteoarthritis: A randomized controlled trial. Annals of Family Medicine. 2013; 11(3): 229–237; Rabago D, Zgierska A, Fortney L, Kijowski R, Mundt M, Ryan M, Grettie J, Patterson JJ. Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up. Journal of Alternative and Complementary Medicine. 2012; 18(4): 408–414; Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, Kijowski R, Grettie J, Wilson J, Miller D. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level randomized controlled trial. American Journal of Physical Medicine & Rehabilitation/Association of Academic Physiatrists. 2013; 92(7): 587–596.
[50] American Academy/Association of Orthopaedic Medicine. About AAOM [2022 Mar 19] www.aaomed.org/About-AAOM.
[51] The Hackett Hemwall Patterson Foundation. Overview [2022 March 19] www.hacketthemwall.org/about/overview/.
[52] TOBI: The Orthobiological Institute. About Us [cited 2022 March 19] www.prpseminar.com/about.
[53] Gunnigle JR. The case for prolotherapy – the opening arguments. Journal of Prolotherapy, Volume 2: Issue 4, December 2011. [cited 2022 March 19] www.neurofascial.com-Prolotherapy-is-Not-Experimental,February-2014.pdf.
[54] Governor Signs "Emerging Therapies Act of 2017”. Sept 22, 2017. [cited 2022 March 19] https://www.arkansasmedicalnews.com/governor-signs-emerging-therapies-act-of-2017-cms-348; Arkansas Emerging Therapies Act of 2017 grants pilot access to regenerative injection therapies. 21 April 2017 [cited 2022 March 19] https://www.regmednet.com/arkansas-emerging-therapies-act-of-2017-grants-pilot-access-to-regenerative-injection-therapies/