Prolotherapy Frequently Asked Questions

Note: These are general questions and general answers. Different doctors may perform treatments in slightly different ways. All concerns, questions, and specifics relating to your personal history, expectations, pain tolerances, or treatment issues should be addressed directly to the doctor planning your Prolotherapy care.


[1] Governor Signs Emerging Therapies Act of 2017 [cited 2022 March 20]

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[7] Rahnama R, Wang M, Dang AC, Kim HT, Kuo AC. Cytotoxicity of local anesthetics on human mesenchymal stem cells. Journal of Bone and Joint Surgery. 2013; 95(2): 132–137.

[8] Anitua E, Troya M, Zalduendo MM, Orive G. The effect of different drugs on the preparation and biological outcomes of plasma rich in growth factors. Annals of Anatomy-Anatomischer Anzeiger. 2014; 196(6): 423–429; Anitua E, Troya M, Zalduendo M, Orive G. Effects of anti-aggregant, anti-inflammatory and anti-coagulant drug consumption on the preparation and therapeutic potential of plasma rich in growth factors (PRGF). Growth Factors. 2015; 33(1): 57–64.

[9] Ramsook RR, Danesh H. Timing of platelet rich plasma injections during antithrombotic therapy. Pain Physician. 2016; 19(7): E1055.